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	Provedor de dados BJMBR (2) Autor Cenedeze,M.A. (2) Bellini,M.H. (1) Cichy,M.C. (1) Câmara,N.O.S. (1) Gloria,M.A. (1) Nürmberg Junior,R. (1) Pacheco-Silva,A. (1) Pessoa,E.A. (1) Rocha,F.G.G. (1) Schor,N. (1) Tristão,V.R. (1) Mais... Palavra-chave Acute renal failure (1) CD31 (1) Cyclooxygenase (1) Endostatin (1) Endothelial cell (1) Gene expression (1) Heme oxygenase 1 (1) Hypoxia (1) Indomethacin (1) Lipopolysaccharide (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2009 (1) 2006 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Collagen XVIII/endostatin expression in experimental endotoxemic acute renal failure BJMBR Cichy,M.C.; Rocha,F.G.G.; Tristão,V.R.; Pessoa,E.A.; Cenedeze,M.A.; Nürmberg Junior,R.; Schor,N.; Bellini,M.H.. Acute renal failure (ARF) is a frequent complication of Gram-negative sepsis, with a high risk of mortality. Lipopolysaccharide (LPS)-induced ARF is associated with hemodynamic changes that are strongly influenced by the overproduction of nitric oxide (NO) through the cytokine-mediated up-regulation of inducible NO synthase. LPS-induced reductions in systemic vascular resistance paradoxically culminate in renal vasoconstriction. Collagen XVIII is an important component of the extracellular matrix expressed in basement membranes. Its degradation by matrix metalloproteases, cathepsins and elastases results in the formation of endostatin, claimed to have antiangiogenic activity and to be a prominent vasorelaxing agent. We evaluated the expression of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Acute renal failure; Lipopolysaccharide; Gene expression; Endostatin; CD31. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009001200005 The blockade of cyclooxygenases-1 and -2 reduces the effects of hypoxia on endothelial cells BJMBR Gloria,M.A.; Cenedeze,M.A.; Pacheco-Silva,A.; Câmara,N.O.S.. Hypoxia activates endothelial cells by the action of reactive oxygen species generated in part by cyclooxygenases (COX) production enhancing leukocyte transmigration. We investigated the effect of specific COX inhibition on the function of endothelial cells exposed to hypoxia. Mouse immortalized endothelial cells were subjected to 30 min of oxygen deprivation by gas exchange. Acridine orange/ethidium bromide dyes and lactate dehydrogenase activity were used to monitor cell viability. The mRNA of COX-1 and -2 was amplified and semi-quantified before and after hypoxia in cells treated or not with indomethacin, a non-selective COX inhibitor. Expression of RANTES (regulated upon activation, normal T cell expressed and secreted) protein and the protective role... Tipo: Info:eu-repo/semantics/article Palavras-chave: Endothelial cell; Hypoxia; Indomethacin; Cyclooxygenase; Heme oxygenase 1. Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000900006 Registros recuperados: 2 Primeira ... 1 ... Última

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